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Research Brief: Calpain Inhibitor All Wrapped Up
21 November 2008. Two groups report the crystal structure of the calcium-dependent protease calpain in complex with its endogenous inhibitor protein, calpastatin...
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DC: Funding We Can Believe In? Perhaps, But Scientists Must Advocate
21 November 2008. As representatives of the world’s 20 richest nations were meeting in Washington, DC, more than 31,000 scientists began arriving a few blocks away...
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DIAN Part 3: Genetic and Data Protection for Volunteers
18 November 2008. DIAN asks a lot of its study volunteers...
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DIAN Part 2: The Science, Inner Workings of the Network
17 November 2008. Scientifically, the Dominantly Inherited Alzheimer Network (DIAN) will test three hypotheses...
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GO TO ALL RESEARCH NEWS  |
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In the spotlight
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Calpain Inhibitor All Wrapped Up
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Two papers in this week’s Nature show the structure of the calcium-dependent protease calpain (multicolored) with its endogenous inhibitor calpastatin (discontinuous purple thread). Calpastatin inhibits calpain activity by binding to its active site. It escapes being cut by looping out around the catalytic amino acid (marked by an asterisk). The structure should facilitate the design of specific calpain inhibitors, which might be neuroprotective in Alzheimer’s and stroke. Image credit: Rachel Hanna |
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DIAN: International Network to Chart AD Preclinical Decade
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The rarest kind of Alzheimer disease, the form that is inherited from parent to child with a cruel 50 percent likelihood, has long been marked by its untapped opportunities. Affected families have made possible both the discovery of the first three Alzheimer’s genes and the elaboration of the amyloid hypothesis. Beyond that, these families have much more to give to research, and gain from it, because the preclinical phase of AD can be studied and targeted for prevention in still-healthy carriers who are certain to develop AD in the future. This has been difficult to do because these families are rare and live all across the globe. Now, an international registry called Dominantly Inherited Alzheimer’s Network (DIAN) is preparing to fill the gap. Starting in January 2009, this 10-center, publicly funded consortium will open its doors for adult children of eFAD families. Carriers, non-carriers, and those who do not want to know their genetic status are welcome to join a comprehensive study that aims to pave the way for future prevention trials.
 DIAN: Registry for eFAD to Chart Alzheimer’s Preclinical Decade
DIAN Part 2: The Science, Inner Workings of the Network
DIAN Part 3: Genetic and Data Protection for Volunteers |
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Participate in Alzforum Survey on Early Detection of AD
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Please participate in a quick survey designed to gauge your perceptions and knowledge of early detection of Alzheimer disease. The survey was created by Alzforum editors and the leadership of the Geoffrey Beene Foundation Alzheimer's Initiative as follow-up to Alzforum's Virtual Town Hall Meeting on June 30, 2008. The Beene Foundation sponsored the Virtual Town Hall meeting to complement the efforts of the Alzheimer's Study Group (ASG), an independent working group mandated by the United States Congress to develop a national strategic plan for Alzheimer disease. Please select the appropriate survey link below. Thank you for your participation.
If you are an Alzheimer Researcher, click here.
If you are a member of the General Public, click here.
View Researcher Survey Results; View Public Survey Results
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What's New
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Comments - Posted 21 November 2008
Read remarks by Will Block about
Green KN et al.
NEWS: Sirtuin Inhibitor Boosts Cognition, Reduces Phospho-tau |
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Comments - Posted 21 November 2008
Read remarks by Nick Fox about Dekosky ST et al.
PAPER: Ginkgo biloba for Prevention of Dementia: A Randomized Controlled Trial. |
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Comments - Posted 21 November 2008
Read remarks by Lon Schneider about "Are you in favor of ICAD going annual?" |
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Comments - Posted 19 November 2008
Read remarks by Bart De Strooper about "Are you in favor of ICAD going annual?" |
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Conferences - Posted 18 November 2008
WFN XVIII World Congress on Parkinson’s Disease and Related Disorders: 13-16 December 2009, Miami Beach, FL, U.S.A. |
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Comments - Posted 18 November 2008
Read remarks by Gerd Multhaup about Hung LW et al.
PAPER: Amyloid-beta peptide (Abeta) neurotoxicity is modulated by the rate of peptide aggregation: Abeta dimers and trimers correlate with neurotoxicity. |
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Comments - Posted 18 November 2008
Read remarks by Yaakov Stern about Roe CM et al.
PAPER: Alzheimer disease and cognitive reserve: variation of education effect with carbon 11-labeled Pittsburgh Compound B uptake. |
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Comments - Posted 18 November 2008
Read remarks by William Polsky about
Green KN et al.
NEWS: Sirtuin Inhibitor Boosts Cognition, Reduces Phospho-tau |
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